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Reference \ Pharmacology
Dermal Absorption Models in Toxicology & Pharmacology
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Jim Riviere,
392 pages, 2005.- Reviews the basic structure and function of skin relative to absorption phenomenon
- Focuses on how experiments are conducted and how the data is analyzed
- Discusses membrane coated fiber technique to assess absorption, the skin component of PBPK models, and in vitro model systems with an intact vasculature
- Covers how the data that quantifies dermal absorption is actually applied to the risk assessment field
- Provides an overview of the QSAR of dermal absorption approach and its application to compounds of toxicological concern
Many experimental methods and mathematical modeling approaches rooted in disciplines outside of toxicology can be effectively applied to estimating dermal absorption. Dermal Absorption Models in Toxicology and Pharmacology explores current approaches and techniques that can be used to quantify dermal absorption with endpoints useful in both toxicology and pharmacology.
The book begins with a review of basic principles and the in vitro and in vivo experimental approaches available for assessing dermal absorption of drugs and chemicals. This is followed by coverage of mathematical or in silico models for quantitating percutaneous absorption and the applications of these techniques to the risk assessment process.
The remainder of the book explores scenarios where the unique properties of the chemicals being studied or the matrix in which they are exposed must be considered and then wraps up with a comparative analysis of chemical permeability in human and animal skin.
Many of the books covering this subject are just too comprehensive and serve primarily as reference works. This book takes a different approach. Jim Riviere's editorial guidance ensures that the information is readable, accessible, authoritative, and concise, making it the perfect resource for familiarizing new researchers and students to the field and updating established scientists.
Non-returnable.
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