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Reference \ Dermatoses Metals and Skin: Topical Effects and Systemic Absorption

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RH Guy, J Hostynek, R Hinz, C Lorence,
Illus., hardcover, 448 pp., 1999.
Addressing the increase of toxic heavy metals in the environment, this groundbreaking reference sets the standard for future research in interactions between the skin and metals and metal compounds—covering the general toxicology of 35 metals and metalloids, their occurrence in the environment, significance in nutrition, skin diffusivity, occupational exposure risks, and immunotoxicity.
Provides a one-of-a-kind compendium of studies on the health hazards of toxic, nonessential metals absorbed through the skin!
Filling an important niche in the literature with a rigorous quantitative analysis of permeability and transport, Metals and the Skin- explores skin permeation factors such as oxidation, ionic charge and radius, electropositivity, redox potential, counter ion, polarity and polarizability, pH, and hydration
presents results of extensive research done in Eastern Europe and the former Soviet Union, previously inaccessible in the West until now
- synthesizes the best research of previous decades with powerful new techniques utilizing radioactive metal isotopes
- reviews data on carcinogenic metals such as arsenic, beryllium, cadmium, chromium, palladium, nickel, and thorium
- evaluates the permeability coefficient (Kp) as a parameter for comparison of percutaneous flux
examines penetrating metal salts in their ionic form, as water soluble charged complexes and organo-metallic compounds
- advocates further study and comprehensive, systematic collection of data on permeation routes and rates in order to arrive at a single predictive algorithm
and more! Referenced with over 1800 bibliographic citations, Metals and the Skin is an indispensable reference for environmental toxicologists, dermatologists, pharmaceutical scientists, cosmetic chemists and biochemists, clinical immunologists and allergists, occupational health physicians, and graduate and medical students in these disciplines.
Special order item, therefore it cannot be canceled once the order has been placed and is non-returnable after it has been received.
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