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| Reference \ General |
Table of Contents (Parts 1-8)
| Contributors
Preface
Part 1
Introduction to Clinical Medicine
1 The Practice of Medicine
The Editors
2 Global Issues in Medicine
Jim Yong Kim / Paul Farmer
3 Decision-Making in Clinical Medicine
Daniel B. Mark
4 Screening and Preventionof Diseases
Gary J. Martin
5 Principles of Clinical Pharmacology
Dan M. Roden
6 Women’s Health
Andrea Dunaif
7 Medical Disorders during Pregnancy
Robert L. Barbieri / John T. Repke
8 Medical Evaluation of the Surgical Patient
Wei C. Lau / Kim A. Eagle9 Geriatric Medicine
Lisa B. Caruso / Rebecca A. Silliman
10 Complementary and Alternative Medicine
Stephen E. Straus
11 Palliative and End-of-Life Care
Ezekiel J. Emanuel / Joshua Hauser / Linda L. Emanuel
e1 The Safety and Quality of Health Care
David W. Bates
e2 Economic Considerations in the Practice of Medicine
David Meltzer
e3 Racial and Ethnic Disparities in Health Care
Joseph R. Betancourt / David Blumenthal
e4 Ethical Issues in Clinical Medicine
Bernard Lo
Part 2
Cardinal Manifestations and Presentation of Diseases
Section 1: Pain
12 Pain: Pathophysiology and Management
Howard L. Fields / Joseph B. Martin
13 Chest Discomfort
Thomas H. Lee
14 Abdominal Pain
William Silen
15 Headache
Peter J. Goadsby / Neil H. Raskin
16 Back and Neck Pain
John W. Engstrom
Section 2: Alterations in Body Temperature
17 Fever and Hyperthermia
Charles A. Dinarello / Reuven Porat
18 Fever and Rash
Elaine T. Kaye / Kenneth M. Kaye
e5 Atlas of Rashes Associated with Fever
Elaine T. Kaye / Kenneth M. Kaye
19 Fever of Unknown Origin
Jeffery A.Gelfand / Michael V. Callahan
20 Hypothermia and Frostbite
Daniel F. Danzl
Section 3: Nervous System Dysfunction
21 Syncope
Mark D. Carlson
22 Dizziness and Vertigo
Robert B. Daroff
23 Weakness and Paralysis
Michael J. Aminoff
24 Gait and Balance Disorders
Lewis Sudarsky
25 Numbness, Tingling, and Sensory Loss
Michael J. Aminoff / Arthur K.Asbury
26 Confusion and Delirium
S. Andrew Josephson / Bruce L. Miller
e6 Memory Loss
Thomas D. Bird / Bruce L. Miller
27 Aphasia, Memory Loss, and Other Focal Cerebral Disorders
M.-Marsel Mesulam
28 Sleep Disorders
Charles A. Czeisler / John W. Winkleman / Gary S. Richardson
Section 4: Disorders of Eyes, Ears, Nose, and Throat
29 Disorders of the Eye
Jonathan C. Horton
30 Disorders of Smell, Taste, and Hearing
Anil K. Lalwani
31 Pharyngitis, Sinusitis, Otitis, and Other Upper Respiratory Infections
Michael A. Rubin / Ralph Gonzales / Merle A. Sande
32 Oral Manifestations of Disease
Samuel C. Durso
e7 Atlas of Oral Manifestations of Disease
Samuel C. Durso / Janet A. Yellowitz
Section 5: Alterations in Circulatory and Respiratory Functions
33 Dyspnea and Pulmonary Edema
Richard M. Schwartzstein
34 Cough and Hemoptysis
Steven E. Weinberger / David A. Lipson
35 Hypoxia and Cyanosis
Eugene Braunwald
36 Edema
Eugene Braunwald / Joseph Loscalzo
e8 Approach to the Patient with a Heart Murmur
Patrick O’Gara / Eugene Braunwald
37 Palpitations
Joseph Loscalzo
Section 6: Alterations in Gastrointestinal Function
38 Dysphagia
Raj K. Goyal
39 Nausea, Vomiting, and Indigestion
William L. Hasler
40 Diarrhea and Constipation
Michael Camilleri / Joseph A. Murray
41 Weight Loss
Carol M. Reife
42 Gastrointestinal Bleeding
Loren Laine
43 Jaundice
Daniel S. Pratt / Marshall M. Kaplan
44 Abdominal Swelling and Ascites
Robert M. Glickman / Roshini Rajapaksa
Section 7: Alterations in Renal and Urinary Tract Function
45 Azotemia and Urinary Abnormalities
Bradley M. Denker / Barry M. Brenner
e9 Atlas of Urinary Sediments and Renal Biopsies
Agnes B. Fogo / Eric G. Neilsen
46 Fluid and Electrolyte Disturbances
Gary G. Singer / Barry M. Brenner
47 Hypercalcemia and Hypocalcemia
Sundeep Khosla
48 Acidosis and Alkalosis
Thomas B. DuBose, Jr.
Section 8: Alterations in Sexual Function and Reproduction
49 Sexual Dysfunction
Kevin T. McVary
50 Hirsutism and Virilization
David A. Ehrmann
51 Menstrual Disorders and Pelvic Pain
Janet E. Hall
Section 9: Alterations in the Skin
52 Approach to the Patient with a Skin Disorder
Thomas J. Lawley / Kim B. Yancey
53 Eczema, Psoriasis, Cutaneous Infections, Acne, and Other Common Skin Disorders
Calvin O. McCall / Thomas J. Lawley
54 Skin Manifestations of Internal Disease
Jean L. Bolognia / Irwin M. Braverman
55 Immunologically Mediated Skin Diseases
Kim B. Yancey / Thomas J. Lawley
56 Cutaneous Drug Reactions
Jean-Claude Roujeau / Robert S. Stern / Bruce C. Wintroub
57 Photosensitivity and Other Reactions to Light
David R. Bickers
e10 Atlas of Skin Manifestations of Internal Disease
Thomas J. Lawley / Stephen Templeton
Section 10: Hematologic Alterations
58 Anemia and Polycythemia
John W. Adamson / Dan L. Longo
59 Bleeding and Thrombosis
Barbara A. Konkle
60 Enlargement of Lymph Nodes and Spleen
Patrick H. Henry / Dan L. Longo
61 Disorders of Granulocytes and Monocytes
Steven M. Holland /John I. Gallin
e11 Atlas of Hematology and Analysis of Peripheral Blood Smears
Dan L. Longo
Part 3
Genetics and Disease
62 Principles of Human Genetics
J. Larry Jameson / Peter Kopp
63 Chromosome Disorders
Terry Hassold / Stuart Schwartz
64 The Practice of Genetics in Clinical Medicine
Susan Miesfeldt / J. Larry Jameson
65 Gene Therapy in Clinical Medicine
Katherine A. High
Part 4
Regenerative Medicine
66 Stem Cell Biology
Minoru S. H. Ko
67 Applications of Stem Cell Biology in Clinical Medicine
Jack A. Kessler
68 Hematopoietic Stem Cells
David T. Scadden / Dan L. Longo
69 Tissue Engineering
Jennifer Anderson /Joseph P. Vacanti
Part 5
Nutrition
70 Nutritional Requirements and Dietary Assessment
Johanna Dwyer
71 Vitamin and Trace Mineral Deficiency and Excess
Robert M. Russell / Paolo M. Suter
72 Malnutrition and Nutritional Assessment
Douglas C. Heimburger
73 Enteral and Parenteral Nutrition Therapy
Bruce R. Bistrian / David F. Driscoll
74 Biology of Obesity
Jeffrey S. Flier / Eleftheria Maratos-Flier
75 Evaluation and Management of Obesity
Robert F. Kushner
76 Eating Disorders
B. Timothy Walsh
Part 6
Oncology and Hematology
Section 1: Neoplastic Disorders
77 Approach to the Patient with Cancer
Dan L. Longo
78 Prevention and Early Detection of Cancer
Otis W. Brawley / Barnett S. Kramer
79 Cancer Genetics
Pat J. Morin / Jeffrey M. Trent / Francis S. Collins / Bert Vogelstein
80 Cancer Cell Biology and Angiogenesis
Robert G. Fenton / Dan L. Longo
81 Principles of Cancer Treatment
Edward A. Sausville / Dan L. Longo
82 Infections in Patients with Cancer
Robert Finberg
83 Cancer of the Skin
Arthur J. Sober / Hensin Tsao / Carl V. Washington
84 Head and Neck Cancer
Everett E. Vokes
85 Neoplasms of the Lung
John D. Minna / Joan H. Schiller
86 Breast Cancer
Marc E. Lippman
87 Gastrointestinal Tract Center
Robert J. Mayer
88 Tumors of the Liver and Biliary Tree
Brian I. Carr
89 Pancreatic Cancer
Yu Jo Chua / David Cunningham
90 Bladder and Renal Cell Carcinomas
Howard I. Scher / Robert J. Motzer
91 Benign and Malignant Diseases of the Prostate
Howard I. Scher
92 Testicular Cancer
Robert J. Motzer / George J. Bosl
93 Gynecologic Malignancies
Robert C. Young
94 Soft Tissue and Bone Sarcomas and Bone Metastases
Shreyaskumar R. Patel / Robert S. Benjamin
95 Carcinoma of Unknown Primary
Gauri R. Varadhachary /James L. Abbruzzese
96 Paraneoplastic Syndromes: Endocrinologic/Hematologic
J. Larry Jameson / Bruce E. Johnson
97 Paraneoplastic Neurologic Syndromes
Joseph Dalmau / Myrna R. Rosenfeld
e12 Thymoma
Dan L. Longo
e13 Late Consequences of Cancer and Its Treatment
Michael C. Perry / Dan L. Longo
Section 2: Hematopoietic Disorders
98 Iron Deficiency and Other Hypoproliferative Anemias
John W. Adamson
99 Disorders of Hemoglobin
Edward J. Benz
100 Megaloblastic Anemia
A. Victor Hoffbrand
101 Hemolytic Anemias and Anemias due to Acute Blood Loss
Lucio Luzzatto
102 Aplastic Anemia, Myelodysplasia, and Related Bone Marrow Failure Syndromes
Neal S. Young
103 Polycythemia Vera and Other Myeloproliferative Diseases
Jerry L. Spivak
104 Acute and Chronic Myeloid Leukemia
Meir Wetzler /John C. Byrd / Clara D. Bloomfield
105 Malignancies of Lymphoid Cells
Dan L. Longo
106 Plasma Cell Disorders
Nikhil C. Munshi / Dan L. Longo / Kenneth C. Anderson
107 Transfusion Biology and Therapy
Jeffery S. Dzieczkowski / Kenneth C. Anderson
108 Hematopoietic Cell Transplantation
Frederick R. Applebaum
Section 3: Disorders of Hemostasis
109 Disorders of Platelets and Vessel Wall
Barbara A. Konkle
110 Coagulation Disorders
Valder Arruda / Katherine High
111 Thrombosis Venous
F.R. Rosendaal / H.R. Büller
112 Antiplatelet, Anticoagulant, and Fibrinolytic Drugs
Jeffery L. Weitz
Part 7
Infectious Diseases
Section 1: Basic Considerations in Infectious Diseases
113 Introduction to Infectious Diseases: Host-Pathogen Interactions
Lawrence C. Madoff / Dennis L. Kasper
114 Molecular Mechanisms of Microbial Pathogenesis
Gerald B. Pier
115 Approach to the Acutely Ill Infected Febrile Patient
Tamar F. Barlam / Dennis L. Kasper
116 Immunization Principles and Vaccine Use
Gerald T. Keusch / Kenneth J. Bart / Mark Miller
117 Health Advice for International Travel
J.S. Keystone / P.E. Kozarsky
e14 Laboratory Diagnosis of Infectious Diseases
Alexander J. McAdam / Andrew B. Onderdonk
Section 2: Clinical Syndromes: Community-Acquired Infections
118 Infective Endocarditis
Adolf W. Karchmer
119 Infections of the Skin, Muscle, and Soft Tissues
Dennis L. Stevens
120 Osteomyelitis
Jeffrey Parsonnet
121 Intraabdominal Infections and Abscesses
Miriam J. Baron / Dennis L. Kasper
122 Acute Infectious Diarrheal Diseases and Bacterial Food Poisoning
Joan R. Butterton / Stephen B. Calderwood
123 Clostridium difficile-Associated Disease, Including Pseudomembranous Colitis
Dale N. Gerding / Stuart Johnson
124 Sexually Transmitted Infections: Overview and Clinical Approach
King K. Holmes
e15 Infectious Complications of Bites and Burns
Lawrence C. Madoff / Florencia Pereyra
Section 3: Clinical Syndromes: Nosocomial Infections
125 Health Care-Associated Infections
Robert A. Weinstein
126 Infections in Transplant Recipients
Robert Finberg /Joyce Fingeroth
Section 4: Approach to Therapy for Bacterial Diseases
127 Treatment and Prophylaxis of Bacterial Infections
Gordon L. Archer / Ronald E. Polk
Section 5: Diseases Caused by Gram-Positive Bacteria
128 Pneumococcal Infections
Daniel M. Musher
129 Staphylococcal Infections
Franklin D. Lowy
130 Strepococcal and Enterococcal Infections
Michael R. Wessels
131 Diphtheria and Other Infections Caused by Corynebacteria and Related Species
William R. Bishai / Jack R. Murphy
132 Infections Caused by Listeria monocytogenes
Elizabeth L. Hohmann / Daniel A. Portnoy
133 Tetanus
Elias Abrutyn
134 Botulism
Elias Abrutyn
135 Gas Gangrene and Other Clostridial Infections
Dennis L. Kasper /Lawrence C. Madoff
Section 6
Diseases Caused by Gram-Negative Bacteria
136 Meningococcal Infections
Lee M. Wetzler
137 Gonococcal Infections
Sanjay Ram / Peter A. Rice
138 Moraxella Infections
Daniel M. Musher
139 Haemophilus Infections
Timothy F. Murphy
140 Infections Due to the HACEK Group and Miscellaneous Gram-Negative Bacteria
Tamar F. Barlam / Dennis L. Kasper
141 Legionella Infection
Miguel Sabria / Victor L. Yu
142 Pertussis and Other Bordetella Infections
Scott A. Halperin
143 Diseases Caused by Gram-Negative Enteric Bacilli
Thomas A. Russo / James R. Johnson
144 Helicobacter Pylori Infections
John C. Atherton / Martin J. Blaser
145 Infections Due to Pseudomonas Species and Related Organisms
Reuben Ramphal
146 Salmonellosis
David A. Pegues / Samuel I. Miller
147 Shingellosis
Philippe Sansonetti / Jean Bergounioux
148 Infections Due to Campylobacter and Related Species
Martin J. Blaser
149 Cholera and Other Vibrioses
Matthew K. Waldor / Gerald T. Keusch
150 Brucellosis
Michael J. Corbel / Nicholas J. Beeching
151 Tularemia
Richard F. Jacobs / Gordon E. Schutze
152 Plague and Other Yersnia Infections
David T. Dennis / Grant L. Campbell
153 Bartonella Infections, Including Cat-Scratch Disease
David H. Spach / Emily Darby
154 Donovanosis
Gavin Hart
Section 7: Miscellaneous Bacterial Infections
155 Nocardiosis
Gregory A. Filice
156 Actinomycosis
Thomas A. Russo
157 Infections Due to Mixed Anaerobic Organisms
Dennis L. Kasper / Ronit Cohen-Poradosu
Section 8: Mycobacterial Diseases
158 Tuberculosis
Mario C. Raviglione / Richard J. O’Brien
159 Leprosy (Hansen’s Disease)
Robert H. Gelber
160 Nontuberculous Mycobacteria
C. Fordham von Reyn
161 Antimycobacterial Agents
Richard J. Wallace / David E. Griffith
Section 9: Spirochetal Disease
162 Syphilis
Sheila A. Lukehart
163 Endemic Treponematoses
Sheila A. Lukehart
164 Leptospirosis
Peter Speelman / Rudy Harkskeerl
165 Relapsing Fever
David T. Dennis
166 Lyme Borreliosis
Allen C. Steere
Section 10: Diseases Caused by Rickettsia, Mycoplasma, and Chlamydia
167 Rickettsial Diseases
David H. Walker / J. Stephen Dumler / Thomas Marrie
168 Infections Due to Mycoplasmas
William M. McCormack
169 Chlamydial Infections
Walter E. Stamm
Section 11: Viral Diseases: General Considerations
170 Medical Virology
Fred Wang /Elliott Kieff
171 Antiviral Chemotherapy, Excluding Antiretroviral Drugs
Lindsey R. Baden / Raphael Dolin
Section 12: Infections Due to DNA Viruses
172 Herpes Simplex Viruses
Lawrence Corey
73 Varicella-Zoster Virus Infections
Richard J. Whitley
174 Epstein-Barr Virus Infections, Including Infectious Mononucleosis
Jeffery I. Cohen
175 Cytomegalovirus and Human Herpesvirus Types 6, 7, and 8
Martin S. Hirsch
176 Molluscum Contagiosum, Monkeypox and Other Poxviruses Excluding Smallpox Virus
Fred Wang
177 Parvovirus Infections
Kevin E. Brown
178 Human Papillomavirus Infections
Richard C. Reichman
Section 13: Infections Due to DNA and RNA Respiratory Viruses
179 Common Viral Respiratory Infections and Severe Acute Respiratory Syndrome (SARS)
Raphael Dolin
180 Influenza
Raphael Dolin
Section 14: Infections Due to Human Immunodeficiency Virus and Other Human Retroviruses
181 The Human Retroviruses
Dan L. Longo /Anthony S. Fauci
182 Human Immunodeficiency Virus Disease: AIDS and Related Disorders
Anthony S. Fauci / H. Clifford Lane
Section 15: Infections Due to RNA Viruses
183 Viral Gastroenteritis
Umesh D. Parashar / Roger I. Glass
184 Enterovirus and Reoviruses Infections
Jeffery I. Cohen
185 Measles (Rubeola)
Anne Gershon
186 Rubella (German Measles)
Anne Gershon
187 Mumps
Anne Gershon
188 Rabies and Other Rhabdovirus Infections
Alan C. Jackson / Eric C. Johannsen
189 Infections Caused by Arthropod and Rodent-Borne Viruses
Clarence J. Peters
190 Ebola and Marburg Viruses
Clarence J. Peters
Section 16: Fungal and Algal Infections
191 Diagnosis and Treatment of Fungal Infections
John E. Edwards
192 Histoplasmosis
Chadi A. Hage / L. Joseph Wheat
193 Coccidioidomycosis
Neil M. Ampel
194 Blastomycosis
Stanley W. Chapman
195 Cryptococcosis
Arturo Casadevall
196 Candidiasois
John E. Edwards
197 Aspergillosis
David W. Denning
198 Mucormycosis
Alan M. Sugar
199 Miscellaneous Mycoses and Algal Infections
Stanley W. Chapman / Donna C. Sullivan
200 Pneumocystis Infection
A. Geroge Smulian /Peter D. Walzer
Section 17: Protozoal and Helminthic Infections: General Considerations
e16 Laboratory Diagnosis of Parasitic Infections
Sharon L. Reed / Charles E. Davis
201 Agents Used to Treat Parasitic Infections
Thomas A. Moore
e17 Pharmacology of Agents Used to Treat Parasitic Infections
Thomas A. Moore
Section 18: Protozoal Infections
202 Ambiasis and Infection with Free-Living Amebas
Sharon L. Reed
203 Malaria
Nicholas J. White / Joel G. Breman
204 Babesiosis
Jeffery Gelfand
e18 Atlas of Blood Smears of Malaria and Babesiosis
Nicholas J. White / Joel G. Breman
205 Leishmaniasis
Barbara L. Herwaldt
206 Trypanosomiasis
Louis V. Kirchhoff
207 Toxoplasma Infections
Lloyd H. Kasper
208 Protozoal Intestinal Infections and Trichomoniasis
Peter F. Weller
Section 19: Helminthic Infections
209 Trichinella and Other Tissue Nematodes
Peter F. Weller
210 Intestinal Nematodes
Peter F. Weller /Thomas B. Nutman
211 Filarial and Related Infections
Peter F. Weller / Thomas B. Nutman
212 Schistosomiasis and Other Trematode Infections
Adel A.F. Mahmoud
213 Cestodes
A. Clinton White, Jr. / Peter F. Weller
Part 8
Bioterrorism and Clinical Medicine
214 Microbioterrorism
H. Clifford Lane / Anthony S. Fauci
215 Chemical Bioterrorism
Charles G. Hurst / Jonathan Newmark / James A. Romano
216 Radiation Bioterrorism
Zelig A. Tochner / Eli Glatstein |
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